Longitudinal comparison between plasma and seminal HIV-1 viral loads during antiretroviral treatment

Revista da Sociedade Brasileira de Medicina Tropical

Lauro Ferreira Da Silva Pinto Neto²  Nilo F.r. Vieira¹  Moacir Soprani¹  Carla B. Cunha²  Valéria P. Cabral²  Reynaldo Dietze²  Rodrigo Ribeiro-rodrigues² 

[1] ,Universidade Federal do Espírito Santo Núcleo de Doenças Infecciosas Cellular and Molecular Immunology LaboratoryVitória ES ,Brazil

关键词: Viral load;    Semen;    HIV-1;    Antiretroviral therapy;    Plasma;    Carga viral;    Sêmen;    HIV-;    Terapia antiretroviral;    Plasma;   

DOI  :  10.1590/S0037-86822003000600008

来源: SciELO

【 摘 要 】

This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naïve patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.

【 授权许可】

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