Longitudinal comparison between plasma and seminal HIV-1 viral loads during antiretroviral treatment

Revista da Sociedade Brasileira de Medicina Tropical

Cabral, Valéria P.¹  Soprani, Moacir¹  Santa Casa de Misericórdia de Vitória, Vitória, Brazil¹  Cunha, Carla B.¹  Ribeiro-Rodrigues, Rodrigo¹  Dietze, Reynaldo¹  Vieira, Nilo F.R.¹  Pinto Neto, Lauro Ferreira da Silva¹  Universidade Federal do Espírito Santo, Vitória, Brazil¹ 

关键词: Viral load;    Semen;    HIV-1;    Antiretroviral therapy;    Plasma;   

DOI  :  10.1590/S0037-86822003000600008

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

This study was designed to investigate the impact of anti-retroviral therapy on both plasma and seminal HIV-1 viral loads and the correlation between viral loads in these compartments after treatment. Viral load, CD4+ and CD8+ T-cell counts were evaluated in paired plasma and semen samples from 36 antiretroviral therapy-naïve patients at baseline and on days 45, 90, and 180 of treatment. Slopes for blood and seminal viral loads in all treated patients were similar (p = 0.21). Median HIV-1 RNA titers in plasma and semen at baseline were 4.95 log10 and 4.48 log10 copies/ml, respectively. After 180 days of therapy, the median viral load declined to 3.15 log10 copies/ml (plasma) and 3.2 log10 copies/ml (semen). At this timepoint 22 patients presented HIV-1 viral load below 400 copies/ml in either plasma or semen, but only 9 had viral loads below 400 copies/ml in both compartments.

【 授权许可】

Unknown