Immunodiagnosis of chronic Chagas' disease using the Tc 46 and Tc 58 antigens

Revista da Sociedade Brasileira de Medicina Tropical

Valéria R.a. Pereira¹  Mineo Nakazawa¹  Veridiana C. Furtado¹  Frederico G.c. Abath¹  Yara M. Gomes¹ 

[1] ,Fundação Instituto Oswaldo Cruz Centro de Pesquisas Aggeu Magalhães Departamento de ImunologiaRecife PE

关键词: T. cruzi;    Insoluble antigens;    Immunodiagnosis;    Chagas' disease;    T. cruzi;    Antígenos insolúveis;    Imunodiagnóstico;    Doença de Chagas;   

DOI  :  10.1590/S0037-86822000000400006

来源: SciELO

【 摘 要 】

The polypeptides of 46 and 58kDa were recognized in different T. cruzi strains (Y, WSL and Colombiana) by serum of all chagasic patients studied. These polypeptides were isolated from T. cruzi Y strain and used in ELISA. The sensitivity and specificity were 97.6% [CI 95%: 86-100%] and 100% [CI 95%: 89.3-100%], respectively when Tc 46 was used. When Tc 58 was used the sensitivity and specificity were 100% [CI 95%: 89.6-100%] and 90.2% [CI 95%: 75.9-96.8%], respectively.

【 授权许可】

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