Revista da Sociedade Brasileira de Medicina Tropical | |
Macrofilaricidal effects of chloroquine on adult Onchocerca volvulus by local infiltration of palpable onchocercal nodules | |
Ronald H. Guderian1  Mariela Anselmi1  Philip J. Cooper1  Martha E. Chico1  | |
[1] ,Hospital VozandesQuito,Ecuador | |
关键词: Onchocerciasis; Nodules; Infiltration; Chloroquine; Oncocercose; Nódulos; Infiltração; Cloroquina; | |
DOI : 10.1590/S0037-86821997000600005 | |
来源: SciELO | |
【 摘 要 】
The macrofilaricidal effects of local infiltration of high concentrations of chloroquine into the capsule of onchocercal nodules on adult worms of Onchocerca volvulus was determined. Six weeks post infiltration, histological examination of single nodules showed all adult worms to be dead. With nodule conglomerates, there was localized action of chloroquine only on the adult worms in the infiltrated nodule, with no diffusion of the drug to adjacent nodules. Chloroquine infiltration of young, recently formed nodules to reduce the adult worm load of infected individuals may be an alternative method to costly nodulectomy.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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