Macrofilaricidal effects of chloroquine on adult Onchocerca volvulus by local infiltration of palpable onchocercal nodules

Revista da Sociedade Brasileira de Medicina Tropical

Ronald H. Guderian¹  Mariela Anselmi¹  Philip J. Cooper¹  Martha E. Chico¹ 

[1],Hospital VozandesQuito,Ecuador

关键词: Onchocerciasis;    Nodules;    Infiltration;    Chloroquine;    Oncocercose;    Nódulos;    Infiltração;    Cloroquina;   

DOI  :  10.1590/S0037-86821997000600005

来源: SciELO

【 摘 要 】

The macrofilaricidal effects of local infiltration of high concentrations of chloroquine into the capsule of onchocercal nodules on adult worms of Onchocerca volvulus was determined. Six weeks post infiltration, histological examination of single nodules showed all adult worms to be dead. With nodule conglomerates, there was localized action of chloroquine only on the adult worms in the infiltrated nodule, with no diffusion of the drug to adjacent nodules. Chloroquine infiltration of young, recently formed nodules to reduce the adult worm load of infected individuals may be an alternative method to costly nodulectomy.

【 授权许可】

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