Kinetics of Trypanosoma cruzi destruction in the mouse spleen

Revista da Sociedade Brasileira de Medicina Tropical

Zulmira M.s. Cordeiro¹  Ana Cristina Gonzalez Dahia¹  Zilton A. Andrade² 

[1] ,FIOCRUZSalvador,Brasil

关键词: Trypanosoma cruzi;    Macrophages;    Spleen;    Trypanosoma cruzi;    Macrófagos;    Baço;   

DOI  :  10.1590/S0037-86821997000100002

来源: SciELO

【 摘 要 】

Massive destruction of parasitized splenic macrophages was histologically observed at the height of a virulent infection caused by Trypanosoma cruzi (Y strain) in the mouse. This was coincident with a sudden drop in parasitemic curve. Most of the animals died at this point, probably due to the liberation of toxic products, such as TNF, following the massive destruction of parasitized cells. However, parasitized-cell destruction indicated the transition from susceptibility to resistance. Although it has been extensively studied in vitro, this study contributes with the morphological counterpart observed in vivo by optical and electron microscopy. When infected animals were specifically treated during early infection transition to chronic phase was immediately observed without splenic parasitism. Animals that apparently recovered from massive cell-destruction in the spleen showed evidences of a rapid restoration of splenic architecture.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License