Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities

Revista da Sociedade Brasileira de Medicina Tropical

Benedito Barraviera¹  Paulo Câmara Marques Pereira¹  Jussara Marcondes Machado¹  Maria Julia De Souza¹  Carlos Roberto G. Lima¹  Paulo Roberto Curi¹  Rinaldo Poncio Mendes¹  Domingos Alves Meira¹ 

关键词: Isoniazid acetylating phenotype;    Paracoccidioidomycosis;    Glucose-6-phosphate dehydrogenase (G6PD);    Glutathione reductase;    Sulfadoxin;    Fenótipo acetilador da isoniazida;    Paracoccidioidomicose;    Glicose-6-fosfato desidrogenase (G6PD);    Glutationa redutase;    Sulfadoxina;   

DOI  :  10.1590/S0037-86821991000200008

来源: SciELO

【 摘 要 】

The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis.

【 授权许可】

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