Isoniazid acetylating phenotype in patients with paracoccidioidomycosis and its relationship with serum sulfadoxin levels, glucose-6-phosphate dehydrogenase and glutathione reductase activities

Revista da Sociedade Brasileira de Medicina Tropical

Barraviera, Benedito¹  Pereira, Paulo Câmara Marques¹  Meira, Domingos Alves¹  Curi, Paulo Roberto¹  Souza, Maria Julia de¹  Mendes, Rinaldo Poncio¹  Lima, Carlos Roberto G.¹  Machado, Jussara Marcondes¹ 

关键词: Isoniazid acetylating phenotype;    Paracoccidioidomycosis;    Glucose-6-phosphate dehydrogenase (G6PD);    Glutathione reductase;    Sulfadoxin;   

DOI  :  10.1590/S0037-86821991000200008

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The authors evaluated the isoniazid acetylating phenotype and measured hematocrit, hemoglobin, glucose-6-phosphate dehydrogenase and glutathione reductase activities plus serum sulfadoxin levels in 39 patients with paracoccidioidomycosis (33 males and 6 females) aged 17 to 58 years. Twenty one (53.84%) of the patients presented a slow acetylatingphenotype and 18(46.16%) a fast acetylating phenotype. Glucose-6-phosphate- dehydrogenase (G6PD) acti vity was decreased in 5(23.80%) slow acetylators and in 4(22.22%) fast acetylators. Glutathione reductase activity was decreased in 14 (66.66%) slow acetylators and in 12 (66.66%) fast acetylators. Serum levels of free and total sulfadoxin Were higher in slow acetylator (p < 0.02). Analysis of the resultspermitted us to conclude that serum sulfadoxin levels are related to the acetylatorphenotype. Furthermore, sulfadoxin levels were always above 50 µg/ml, a value considered therapeutic. Glutathione reductase deficiency observed in 66% of patients may be related to the intestinal malabsorption of nutrients, among them riboflavin, a FAD precursor vitamin, inpatients with paracoceidioidomycosis.

【 授权许可】

Unknown