DIARRHEA OUTBREAK IN PERNAMBUCO, BRAZIL, ASSOCIATED WITH A HEAT-STABLE CYTOTOXIC ENTEROTOXIN PRODUCED BY Aeromonas caviae

Revista do Instituto de Medicina Tropical de São Paulo

Ana Carolina Amaral Lopes¹  Luciano Moura Martins¹  Maria Silvia Viccari Gatti¹  Cristhiane Moura Falavina Dos Reis¹  Ernesto Hofer¹  Tomomasa Yano¹ 

关键词: Diarrhea outbreak;    Aeromonas caviae;    Cytotoxic enterotoxin;    Virulence factors;   

DOI  :  10.1590/S0036-46652015000400013

来源: SciELO

【 摘 要 】

SUMMARY In the present study enterotoxic and cytotoxic activities of twenty Aeromonas caviaestrains were examined. They originated from fecal specimens of patients with acute diarrhea during an outbreak in Brazil in 2004. Culture supernatants of fourteen strains (70%) caused fluid accumulation in rabbit ileal intestinal loops and in suckling mice assays, and also showed a cytotoxic activity in Vero and Caco-2 cells. The enterotoxic and cytotoxic factors were heat-stable after culture supernatants treatment at 100 ºC. The results revealed that A. caviaestrains produce a putative diarrheagenic virulence factor, a heat-stable cytotoxic enterotoxin that could be linked to the diarrhea outbreak that took place in Brazil.

【 授权许可】

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