HIV AND HCV COINFECTION: PREVALENCE, ASSOCIATED FACTORS AND GENOTYPE CHARACTERIZATION IN THE MIDWEST REGION OF BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo

Solange Zacalusni Freitas¹  Sheila Araújo Teles¹  Paulo Cesar Lorenzo¹  Marco Antonio Moreira Puga¹  Tayana Serpa Ortiz Tanaka¹  Danilo Yamamoto Thomaz¹  Regina Maria Bringel Martins¹  Angelita Fernandes Druzian¹  Andréa Siqueira Campos Lindenberg¹  Marina Sawada Torres¹  Sérgio A. Pereira¹  Livia Melo Villar¹  Elisabete Lampe¹  Ana Rita Coimbra Motta-castro¹ 

关键词: Coinfection;    HCV;    HIV;    Prevalence;   

DOI  :  10.1590/S0036-46652014000600011

来源: SciELO

【 摘 要 】

A cross-sectional study on prevalence, associated factors and genotype distribution of HCV infection was conducted among 848 HIV-infected patients recruited at reference centers in the Midwest Region of Brazil. The prevalence rate of HIV-HCV coinfection was 6.9% (95% CI: 5.2 to 8.6). In multivariable analysis, increasing age, use of illicit drugs (injection and non-injection), a history of blood transfusion before 1994, and the absence of a steady partnership were significant independent associated factors for HIV-HCV coinfection. The phylogenetic analysis based on the NS5B region revealed the presence of two major circulating genotypes of HCV: genotypes 1 (58.3%) and 3 (41.7%). The prevalence of HIV-HCV coinfection was lower than those reported in studies conducted with HIV-infected patients in different regions of Brazil, due to the fact that illicit drug use is not a frequent mode of HIV transmission in this region of Brazil. Serologic screening of HIV-patients for HCV before initiating antiretroviral treatment, a comprehensive identification of associated factors, and the implementation of effective harm reduction programs are highly recommended to provide useful information for treatment and to prevent HCV coinfection in these patients.

【 授权许可】

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