Evaluation of seroepidemiological toxoplasmosis in HIV/AIDS patients in the south of Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Graciela Augusto Xavier¹  Beatris Gonzalez Cademartori¹  Nilton Azevedo Da Cunha Filho¹  Nara Amélia Da Rosa Farias¹ 

[1] ,Federal University of Pelotas Institut of Biology Departament of Microbiology and Parasitology Rio Grande do Sul ,Brazil

关键词: Toxoplasmosis;    AIDS;    Toxoplasma gondii;    Neurotoxoplasmosis;    Ocular toxoplasmosis;   

DOI  :  10.1590/S0036-46652013000100005

来源: SciELO

【 摘 要 】

Toxoplasmosis is considered one of the opportunistic infections for individuals with the Acquired Immunodeficiency Syndrome (AIDS), and is also a major cause of morbidity and mortality. The aim of this study was to evaluate the prevalence of neurotoxoplasmosis, ocular toxoplasmosis and antibodies for Toxoplasma gondii in HIV-positive patients attending the SAE (Specialized Assistance Service for HIV/AIDS), as well as to associate their serological profile with epidemiological and clinical data. A total of 250 patients participated in the study from December, 2009 to November, 2010. Serological analysis was performed using the indirect immunofluorescent technique; epidemiological data were gathered by a questionnaire, and clinical history was based on the analysis of medical charts. Prevalence of seropositivity was 80%, with history of neurotoxoplasmosis in 4.8% and of ocular toxoplasmosis in 1.6% of the patients. The Highly Active Antiretroviral Treatment (HAART) was not used by 32% of the patients, 18.4% of the patients had CD4+ T- lymphocyte count less than 200 cells/mm³ and 96.8% of them were not aware of the modes of disease transmission. These findings led us to conclude that the study population is at high risk of clinical toxoplasmosis, because of both reactivation of infection in the seropositive patients who do not make a regular use of HAART, and primo-infection in seronegative patients worsened by an unawareness of the modes of infection reported in this study.

【 授权许可】

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