Evaluation of the resistance to Schistosoma mansoni infection in Nectomys squamipes (Rodentia: Cricetidae), a natural host of infection in Brazil

Revista do Instituto de Medicina Tropical de São Paulo

Arnaldo Maldonado Jr.²  José Roberto Machado E Silva¹  Rosângela Rodrigues E Silva²  Henrique Leonel Lenzi¹  Luis Rey² 

[1] ,Oswaldo Cruz Foundation Oswaldo Cruz Institute FIOCRUZRio de Janeiro RJ ,Brasil

关键词: Nectomys squamipes;    Reinfection;    Immunity;    Wild rodent;    Experimental schistosomiasis;    Schistosoma mansoni;   

DOI  :  10.1590/S0036-46651994000300001

来源: SciELO

【 摘 要 】

The development of resistance in three stages throughout an active infection (pre-ovular, acute and initial chronic stages) was studied, comparing the total number of adult worms recovered from the reinfected group and the control groups. It was shown that Nectomys squamipes was unable to develop resistance in the tested conditions and, on the other hand, reinfection in the pre-ovular period of the parasite led the rodent to present the phenomenonacilitation, with reduction of natural resistance and an increase in the parasite load. These results suggest the existence of other forms of immunity diverse from the concomitant immunity in the host-parasite relationship, according to the employed model.

【 授权许可】

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