Oogram studies in mice infected with Schistosoma mansoni and treated with dexamethasone

Revista do Instituto de Medicina Tropical de São Paulo

Marco Victor Hermeto¹  Rosilene Siray Bicalho¹  Roney Elias Da Silva¹  Alan Lane De Melo¹  Leógenes Horácio Pereira¹ 

关键词: Schistosoma mansoni;    Schistosomiasis;    Dexamethasone;    Glucocorticoids;    Immunossupression;    Oogram;   

DOI  :  10.1590/S0036-46651994000200001

来源: SciELO

【 摘 要 】

Mice infected with about 90 cercariae of Schistosoma mansoni (LE strain) were treated during five consecutive days with dexamethasone (50 mg/Kg, subcutaneously), starting on the 42th day of infection. Groups of five mice were then daily sacrificed from the first day after onset of treatment until the first day after. The perfusion of the portal system was performed and a piece of the intestine was processed for qualitative and quantitative oograms. This treatment carries to larger numbers of eggs in the tissues of treated mice, when compared with untreated groups. No changes were observed in the kinetics of oviposition, as all stages of viable eggs were observed in the tissues of treated and control mice. These data reinforce the hypothesis of a partial blockade of the egg excretion in immunossupressed mice.

【 授权许可】

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