Kinectics of the pulmonary phase of Schistosoma mansoni in mice treated with dexamethasone

Revista do Instituto de Medicina Tropical de São Paulo

Marco Victor Hermeto¹  Rosilene Siray Bicalho¹  Alan Lane De Melo¹  Leógenes Horácio Pereira¹ 

[1] ,Universidade Federal de Minas Gerais Grupo Interdepartamental de Estudos Sobre Esquistossomose Belo Horizonte MG ,Brasil

关键词: Schistosoma mansoni;    Schistosomiasis;    Dexamethasone;    Glucocorticoids;   

DOI  :  10.1590/S0036-46651990000300004

来源: SciELO

【 摘 要 】

In the experimental schistosomiasis mansoni glucocorticoids cause a reduction in the worm burden when administered in the week of infection or, the longest, at the next week. In order to determinate the probable(s) site(s) of reduction of the worm burden, mice were infected with cercariae of LE strain of S. mansoni and dexamethasone was administered daily (50 mg/kg, subcutaneously) starting 1 hour before infection until the eighth day. Mice were sacrificed daily starting on the third day after infection until the ninth day, and schistosomula from lungs were collected. Six weeks after infection, the remaining mice were sacrificed and perfused for adult worm recovery. Analysis of the results showed that the non-treated mice presented larger numbers of lung larvae than the treated ones, and this difference was also found later in the worm burden in the portal system. This difference may reflect the early death of larvae in treated animals, before or after reaching the lungs.

【 授权许可】

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