Antibody response to heat-inactivated hepatitis B vaccine (CLB-3mg) in hemodialysis patients and occupational risk personnel: a one year follow-up

Revista do Instituto de Medicina Tropical de São Paulo

C. F. T. Yoshida²  C. Takahashi¹  L. A. C. Mercadante²  I. F. Camargo¹  H. G. Schatzmayr² 

[1],Fundação Oswaldo Cruz Departamento de Virologia Rio de Janeiro,Brazil

关键词: Hepatitis B vaccine;    Immune Response;    Hemodialysis;   

DOI  :  10.1590/S0036-46651988000100002

来源: SciELO

【 摘 要 】

Immune response against hepatitis B vaccine (CLB 3mg) was evaluated in 59 hemodialysis patients and 20 occupational risk personnel. Seroconversion was induced in 52.5% and 70.0% respectively. Twelve months after the first dose, 37.5% of patients and 60.0% of occupational risk personnel had detectable anti-HBs level. Antibody level was expressed in sample ratio units (SRU). Considering only the responders, in the patients group 38.7% had a low anti-HBs response (2.1-9.9 SRU) 32.3% a medium response (10-99.9 SRU) and 29.0% a high response (>100 SRU) while in occupational risk personnel these values were 14.3%, 64.3% and 21.4% respectively. The authors suggest the use of HBV vaccines with more elevated HBsAg concentration or a reinforced immunization schedule to improve the anti-HBs response not only for patients but also for healthy persons.

【 授权许可】

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