Revista Brasileira de Anestesiologia | |
Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats | |
Lanucha Fidelis Da Luz Moura1  Silvana Bellini Vidor1  Anelise Bonilla Trindade1  Priscilla Domingues Mörschbächer1  Nilson Oleskovicz1  Emerson Antonio Contesini1  | |
关键词: NSAIDs; Carrageenan; Pain; Spinal cord; AINE; Carragenina; Dor; Medula espinhal; AINE; Carragenina; Dolor; Médula espinal; | |
DOI : 10.1016/j.bjane.2013.10.020 | |
来源: SciELO | |
【 摘 要 】
BACKGROUND AND OBJECTIVE: Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats. METHODS: Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I received saline solution 5 µL, while Group II received meloxicam 30 mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesy meter every 30 min during a 4-h period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after treatment from baseline. RESULTS: The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165 min, however, there was no statistical significance (p = 0.835) for this difference. CONCLUSION: Subarachnoid meloxicam at a dose of 30 µg animal-1 did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.
【 授权许可】
CC BY-NC-ND
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