Analysis of childhood leukemia mortality trends in Brazil, from 1980 to 2010

Jornal de Pediatria

Franciane F. Silva¹  Eliana Zandonade¹  Glaucia P. Zouain-figueiredo¹ 

关键词: Infant mortality;    Leukemia;    Linear models;    Child;    Adolescent;    Mortalidade infantil;    Leucemia;    Modelos lineares;    Criança;    Adolescente;   

DOI  :  10.1016/j.jped.2013.12.013

来源: SciELO

【 摘 要 】

OBJECTIVE: Leukemias comprise the most common group of cancers in children and adolescents. Studies conducted in other countries and Brazil have observed a decrease in their mortality.This study aimed to evaluate the trend of mortality from leukemia in children under 19 years of age in Brazil, from 1980 to 2010. METHODS: This was an ecological study, using retrospective time series data from the Mortality Information System, from 1980 to 2010. Calculations of mortality rates were performed, including gross, gender-specific, and age-based. For trend analysis, linear and semi-log regression models were used. The significance level was 5%. RESULTS: Mortality rates for lymphoid and myeloid leukemias presented a growth trend, with the exception of lymphoid leukemia among children under 4 years of age (percentage decrease: 1.21% annually), while in the sub-group "Other types of leukemia", a downward trend was observed. Overall, mortality from leukemia tended to increase for boys and girls, especially in the age groups 10-14 years (annual percentage increase of 1.23% for males and 1.28% for females) and 15-19 years (annual percentage increase of 1.40% for males and 1.62% for females). CONCLUSIONS: The results for leukemia generally corroborate the results of other similar studies. A detailed analysis by subgroup of leukemia, age, and gender revealed no trends shown in other studies, thus indicating special requirements for each variable in the analysis.

【 授权许可】

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