Cognitive reserve and the severity of Alzheimer’s disease

Arquivos de Neuro-Psiquiatria

Margarida Sobral¹  Maria Helena Pestana¹  Constança Paúl¹ 

关键词: Alzheimer´s disease;    cognitive reserve;    education;    leisure activities;    lifelong occupation;    doença de Alzheimer;    reserva cognitiva;    educação;    atividades de lazer;    ocupação ao longo da vida;   

DOI  :  10.1590/0004-282X20150044

来源: SciELO

【 摘 要 】

Alzheimer´s disease (AD) is a clinical syndrome caused by neurodegeneration and characterized by a progressive deterioration in cognitive ability and capacity for independent living. Cognitive reserve (CR) describes the capacity of the adult brain to cope with the effects of the neurodegenerative process and to minimize the clinical manifestation of pathology of dementia. The aim of this study was to evaluate the association of CR and the severity of AD.Method This study was cross-sectional. Functional and neuropsychological abilities of 75 outpatients with probable AD diagnosis were evaluated. Patients completed two questionnaires, “Participation in leisure activities throughout life” and CR Questionnaire.Result The relationship between Clinical Dementia Rating (CDR) and the level of CR was statistically significant (likelihood ratio (LR), p = 0.015).Conclusion The level of CR influenced the severity of dementia. This study suggests that AD patients with higher CR may benefit against cognitive decline after diagnosis of AD.

【 授权许可】

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