Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study

Arquivos de Neuro-Psiquiatria

Michelle Dias Santos Santiago¹  Deusvenir De Souza Carvalho¹  Alberto Alain Gabbai¹  Mariana Machado Pereira Pinto¹  Andrea Regina Correa Moutran¹  Thais Rodrigues Villa¹ 

关键词: chronic migraine;    adults;    prophylaxis;    amitriptyline;    aerobic exercise;    migrânea crônica;    adultos;    profilaxia;    amitriptilina;    exercício aeróbio;   

DOI  :  10.1590/0004-282X20140148

来源: SciELO

【 摘 要 】

To compare the preventive treatment benefits of amitriptyline and aerobic exercise or amitriptyline alone in patients with chronic migraine.Method Sixty patients, both genders, aged between 18 and 50 years, with a diagnosis of chronic migraine, were randomized in groups called amitriptyline and aerobic exercise or amitriptyline alone. The following parameters were evaluated: headache frequency, intensity and duration of headache, days of the analgesic medication use, body mass index (BMI), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) scores. Results In the evaluated parameters, was observed decrease in headache frequency (p=0.001), moderate intensity (p=0.048), in headache duration (p=0.001), the body mass index (p=0.001), Beck Depression Inventory (p=0.001) and Beck Anxiety Inventory scores (p=0.001), when groups were compared in the end of third month. Conclusion In this study, the amitriptyline was an effective treatment for chronic migraine, but its efficacy was increased when combined with aerobic exercise.

【 授权许可】

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