Turbidimetric determination of antidepressant amitriptyline in fia system exploiting the ion-pair formation with sodium lauryl sulphate

Química Nova

Silveira, Gustavo¹  Universidade Federal de Alfenas, Alfenas, Brasil¹  Tarley, César Ricardo Teixeira¹ 

关键词: flow injection turbidimetry;    amitriptyline;    sodium lauryl sulphate.;   

DOI  :  10.1590/S0100-40422008000700010

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The present work purposes the development of an analytical method for amitriptyline determination in pharmaceutical formulations using FIA system. It was based on interaction of amitriplyline with sodium lauryl sulphate in acid medium (pH 2.5) resulting in the ion-pair formation turbidimetrically detected at 410 nm. The fitting regression equation for range curve from 2.0 x 10-3 up to 3.2 x 10-3 mol L-1 was found to be analytical signal = -2.7417 + 0.1538 [amitriptyline] (r = 0.99991) with a detection limit of 1.8 x 10-3 mol L-1. The precision assessed as relative standard deviation (n = 10) was found to be 2.40 and 1.94%, for the respective concentration of amitriplyline 2.0 x 10-3 and 3.2 x 10-3 mol L-1 and the sample throughout was 60 h-1. The accuracy of method was successfully assessed in pharmaceutical formulation after comparison with a reference analytical method.

【 授权许可】

Unknown