Low specificity and sensitivity of smell identification testing for the diagnosis of Parkinson?s disease

Arquivos de Neuro-Psiquiatria

Mayela Rodríguez-violante¹  Paulina Gonzalez-latapi¹  Azyadeh Camacho-ordoñez¹  Daniel Martínez-ramírez¹  Hugo Morales-briceño¹  Amin Cervantes-arriaga¹ 

关键词: Parkinson?s disease;    University of Pennsylvania Smell Identification Test;    olfaction;    diagnostic test;    doença de Parkinson;    University of Pennsylvania Smell Identification Test;    olfato;    teste de diagnostic;   

DOI  :  10.1590/0004-282X20130190

来源: SciELO

【 摘 要 】

Objective: The aim of this study is to determine if the University of Pennsylvania’s Smell Identification Test (UPSIT) is an accurate diagnostic tool for olfactory dysfunction in Parkinson’s disease (PD). Method: We included 138 non-demented PD subjects and 175 control subjects matched by gender. Smell identification was tested using UPSIT. Results: The mean number of UPSIT items correctly identified by controls was 27.52±5.88; the mean score for PD subjects was 19.66±6.08 (p=<0.001). UPSIT sensitivity was 79.7% with a specificity of 68.5% using a cut-off score of ≤25. The overall accuracy for the diagnosis of PD was of 75.3%. Conclusion: UPSIT accuracy and specificity were lower than what has been previously reported. Our data demonstrates that 17.5% of items of the UPSIT were not well identified by healthy controls. Further research of the identification of a truly cross-cultural test is warranted.

【 授权许可】

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