Brain tissue oxidative damage as a possible mechanism for the deleterious effect of a chronic high dose of estradiol on learning and memory in ovariectomized rats

Arquivos de Neuro-Psiquiatria

Fatimeh Khodabandehloo¹  Mahmoud Hosseini¹  Ziba Rajaei¹  Mohammad Soukhtanloo¹  Esmaeil Farrokhi¹  Mohsen Rezaeipour¹ 

关键词: learning;    memory;    ovariectomy;    estradiol;    morris water maze;    oxidative stress;    aprendizado;    memória;    ovariectomia;    estradiol;    Labirinto Aquático de Morris;    estresse oxidativo;   

DOI  :  10.1590/0004-282X20130027

来源: SciELO

【 摘 要 】

In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p≪0.01 and p≪0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q1 compared to Sham and OVX groups (p≪0.05 and p≪0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p≪0.05 and p≪0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.

【 授权许可】

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