Immunohistochemical Evidence for the Presence of Progesterone Receptor in Rat Submandibular Glands

Cell Structure and Function

Satoru Ozono¹  Yumi Ito¹  Minoru Onozuka²  Kazuyoshi Sato¹ 

[1] Department of Pathology, Kanagawa Dental College;Department of Anatomy, Gifu University School of Medicine

关键词: Progesterone;    progesterone receptor;    submandibular glands;    testectomy;    ovariectomy;    estradiol;   

DOI  :  10.1247/csf.16.511

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(9)Cited-By(10)Immunohistochemical analysis of progesterone receptor was carried out in rat submandibular glands. Immunoreactivity to progesterone receptors was found in cell nuclei of the intralobular duct system within male and female rat submandibular glands. The female glands contained more immunoreactive cells than the male glands. In ovariectomized rats progesterone receptor-containing cells decreased in number while testectomized glands revealed an increase. When estradiol was administered to gonadectomized rats of both sexes, the immunoreactivity in cells of the intralobular duct system markedly increased. These results suggest the possibility that progesterone may modulate various metabolic functins in the rat submandibular glands.

【 授权许可】

Unknown