In vitro effect of progesterone on human melanoma (BLM) cell growth

International Journal of Clinical and Experimental Medicine

Pandurangan Ramaraj¹  James L Cox¹ 

关键词: Progesterone;    human melanoma (BLM) cells;    cell growth;    autophagy;    3-methyladenine (3-MA) rescue;    RU-486;    progesterone receptor;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Epidemiological data suggest there is a female sex advantage in melanoma skin cancer. Female sex hormones have been attributed to this protection. There has been no experimental evidence to link female sex hormones directly with melanoma protection until our recently published work on mouse melanoma (B16F10) cells. Our recently published work showed that progesterone significantly inhibited mouse melanoma cell growth in vitro. This study was extended to human melanoma (BLM) cells. Research work revealed that progesterone inhibited human melanoma cell growth also in vitro. The mechanism of inhibition was due to autophagy and this effect of progesterone was not mediated through progesterone receptor.

【 授权许可】

Unknown