Decreased nitric oxide levels in the hippocampus may play a role in learning and memory deficits in ovariectomized rats treated by a high dose of estradiol

Arquivos de Neuro-Psiquiatria

Reihaneh Sadeghian²  Masoud Fereidoni²  Mohammad Soukhtanloo²  Hamid Azizi-malekabadi¹  Mahmoud Hosseini¹ 

[1] ,Ferdowsi University of Mashhad Faculty of Sciences Department of BiologyMashhad,Iran

关键词: estradiol;    rat;    hippocampus;    nitric oxide;    estradiol;    rato;    hipocampo;    óxido nítrico;   

DOI  :  10.1590/S0004-282X2012001100010

来源: SciELO

【 摘 要 】

The effects of a high estradiol dose on memory and on nitric oxide metabolites in hippocampal tissues were investigated. Sham-Est and OVX-Est Groups were treated with 4 mg/kg of estradiol valerate for 12 weeks. Time latency and path length were significantly higher in the Sham-Est and OVX-Est Groups than in the Sham and OVX Groups, respectively (p<0.001). The animals in the Sham-Est and OVX-Est Groups spent lower time in the target quadrant (Q1) than those of the Sham and OVX Groups during the probe trial test (p<0.05 and <0.001, respectively). Significantly lower nitric oxide metabolite levels in the hippocampi of the Sham-Est and OVX-Est Groups were observed than in the Sham and OVX ones (p<0.001). These results suggest that decreased nitric oxide levels in the hippocampus may play a role in the learning and memory deficits observed after treatment with a high dose of estradiol, although the precise underlying mechanisms remain to be elucidated.

【 授权许可】

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