Hippocampal sharp wave-ripple (SWR) associated sequence activity, commonly referred to as replay, hasgenerally been thought of as mediating the transfer of recent experience into the neocortex. However, anumber of recent studies have shown that the content of sequences is not limited to recent experience. Toinvestigate whether internally generated stimuli, such as appetitive motivational states, affect the content ofSWR-associated spiking activity, we recorded from ensembles of CA1 place cells while rats were performinga motivational shift task on a simple T-maze. Rats were food restricted or water restricted on alternatingdays and trained to make a left turn for food and right turn for water. We found that SWR-associated spikingactivity recorded prior to task performance was correlated with motivational state and overall behaviouralchoices, suggesting that it also mediates retrieval of past behavioural episodes to facilitate planning formotivationally relevant outcomes.
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Motivational State Influences the Content of Hippocampal Sequences
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