Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of Scans Without Evidence of Dopaminergic Deficit (SWEDDs)

Arquivos de Neuro-Psiquiatria

Marco A. T. Utiumi²  André C. Felício¹  Conrado R. Borges²  Vera L. Braatz²  Sheyla A. S. Rezende²  Renato P. Munhoz²  Rodrigo A. Bressan¹  Henrique B. Ferraz¹  Hélio A. G. Teive² 

[1] ,Universidade Federal do Paraná Hospital de Clínicas Internal Medicine DepartmentCuritiba PR ,Brazil

关键词: Parkinson disease;    scans without evidence of dopaminergic deficit;    tomography;    emission-computed;    single-photon;    Tc-99mtrodat- 1;    dopamine transporter;    doença de Parkinson;    exames sem evidência de déficit dopaminérgico;    tomografia computadorizada de emissão de fóton único;    Tc-99m-trodat-1;    transportador de dopamina;   

DOI  :  10.1590/S0004-282X2012000900004

来源: SciELO

【 摘 要 】

The clinical diagnosis of Parkinson's disease (PD) is susceptible to misdiagnosis, especially in the earlier stages of the disease. Recently, in vivo imaging techniques assessing the presynaptic dopamine transporter (DAT) have emerged as a useful tool in PD diagnosis, improving its accuracy. OBJECTIVE: It was to illustrate the clinical usefulness of a brain single-photon emission computed tomography (SPECT) DAT ligand, and highlight relevant aspects of scans without evidence of dopaminergic deficit (SWEDDs) in this context. CASES: We described four representative patients with clinically unclear parkinsonian syndromes who underwent [99mTc]-TRODAT-1 SPECT and reviewed the clinical implications. CONCLUSION: DAT-SPECT is an important, cost-effective, technique for the differential diagnosis of parkinsonian syndromes. Additionally, SWEDD cases present clinical and paraclinical peculiarities that may retrospectively identify them as essential/dystonic tremor. The lack of histopathological data limits further conclusions.

【 授权许可】

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