Metabolic syndrome and dementia associated with Parkinson's disease: impact of age and hypertension

Arquivos de Neuro-Psiquiatria

Arthur Oscar Schelp²  Cristiane Lara Mendes-chiloff²  Rodrigo Bazan²  Vanessa Cristina Paduan²  Ana Beatriz Maringolo Pioltini¹ 

[1] ,São Paulo State University Júlio de Mesquita Filho Botucatu Medical School Department of Neurology, Psychology and PsychiatryBotucatu SP ,Brazil

关键词: dementia;    Parkinson's disease;    dyslipidemia;    hypertension;    demência;    doença de Parkinson;    dislipidemia;    hipertensão;   

DOI  :  10.1590/S0004-282X2012000200008

来源: SciELO

【 摘 要 】

OBJECTIVE: To determine correlations between age and metabolic disorders in Parkinson's disease (PD) patients. METHODS: This observational cross-sectional study included brief tests for dementia and the Mattis test. Signals of metabolic syndrome were evaluated. RESULTS: There was no significant effect from the presence of hypertension (OR=2.36 for patients under 65 years old and OR=0.64 for patients over 65), diabetes or hypercholesterolemia regarding occurrences of dementia associated with PD (24% of the patients). The study demonstrated that each year of age increased the estimated risk of dementia in PD patients by 9% (OR=1.09; 95%CI: 1.01-1.17). CONCLUSION: There was no evidence to correlate the presence of metabolic syndrome with the risk of dementia that was associated with PD. The study confirmed that dementia in PD is age dependent and not related to disease duration.

【 授权许可】

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