Identification of wearing-off manifestations (reduction of levodopa effect) in Parkinson's disease using specific questionnaire and comparison of the results with routine ambulatory evaluations

Arquivos de Neuro-Psiquiatria

Luciano Magalhães Melo¹  Hsin Fen Chien¹  Egberto Reis Barbosa¹ 

[1] ,University of São Paulo School of Medicine Department of NeurologySão Paulo SP ,Brazil

关键词: Parkinson's disease;    wearing-off;    nonmotor fluctuations;    screening;    doença de Parkinson;    wearing-off;    flutuações não motoras;    rastreamento;   

DOI  :  10.1590/S0004-282X2010000400007

来源: SciELO

【 摘 要 】

This study had the objective to verify if the presence of wearing-off phenomenon in patients with Parkinson's disease (PD) could be better identified by the administration of the "Wearing-off Questionnaire Card" (QC). The participant patients were first evaluated by resident doctors in neurology and then invited to answer the QC for detection of motor and nonmotor wearing-off manifestations. Seventy and nine patients were enclosed in the study. The questionnaire revealed that 63 patients (80%) presented wearing-off, whereas the consultation by the resident doctors only identified 33 subjects (41%) with this phenomenon. The motor wearing-off manifestations were more frequent then the nonmotor. We conclude that the administration of the QC in patients with PD may be a useful tool for the diagnosis of wearing-off phenomena.

【 授权许可】

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