Ultrastructural study of the lateral ventricle choroid plexus in experimental hydrocephalus in Wistar rats

Arquivos de Neuro-Psiquiatria

Daniela Pretti Da Cunha Tirapelli²  Luiza Da Silva Lopes¹  João José Lachat¹  Benedicto Oscar Colli¹  Luís Fernando Tirapelli¹ 

[1] ,University of São Paulo Medicine School of Ribeirão Preto Department of Surgery and AnatomyRibeirão Preto SP ,Brazil

关键词: hydrocephalus;    choroid plexus;    ultrastructural study;    rat;    hidrocefalia;    plexos corióides;    estudo ultra-estrutural;    rato;   

DOI  :  10.1590/S0004-282X2007000600010

来源: SciELO

【 摘 要 】

Hydrocephalus is one of the most frequent and complex neurological diseases characterized by the abnormal buildup of cerebrospinal fluid (CSF) in the ventricles of the brain, due to an altered CSF dynamics. To detect possible ultrastructural alterations of the lateral ventricles choroid plexus (responsible for the CSF production), rats seven days after birth were submitted to an intracisternal injection of 20% kaolim (hydrated aluminum silicate) for the hydrocephalus induction. Twenty-eight or 35 days after injection, injected animals and respective controls were processed for observation under a transmission electron microscopy. Alterations found: presence of concentric cell membrane fragments, larger number of primary and secondary lysossomes, vacuoles, and cytoplasmic vesicles, and an enlargement of the intercellular space and between the basolateral interdigitation of the choroid epithelium. The alterations observed are probably associated to an increase of the ventricular pressure, inducing morpho-functional effects on the choroid plexus integrity.

【 授权许可】

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