Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats

Arquivos de Neuro-Psiquiatria

Hiroshi Nakano²  Benedicto Oscar Colli¹  Luiza Da Silva Lopes¹ 

[1] ,Marília Medical SchoolMarília SP ,Brazil

关键词: cats;    focal cerebral ischemia;    mild hypothermia;    neuroprotection;    gatos;    isquemia cerebral focal;    hipotermia leve;    neuroproteção;   

DOI  :  10.1590/S0004-282X2007000500015

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild hypothermia (32º C). Brain coronal sections 2mm thick were stained with 2,3,5-triphenyltetrazolium hydrochloride, photographed and evaluated with software for volume calculation. RESULTS:Cortical ischemia was found in 7 and basal ganglia ischemia in 8 animals of group 1 and in both regions in 5 animals of group 2 (no difference: p=0.6499 for cortical; p=0.3498 for basal ganglia). No ischemia was found in 5 animals of group 2 and in none of group 1 (significant difference, p=0.0325). The infarct volume was greater in group 1 than 2 (p=0.0433). CONCLUSION: Mild hypothermia did not interfere with location of ischemia, but it was effective for reducing the infarct volume.

【 授权许可】

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