Ganglioglioma: comparison with other low-grade brain tumors

Arquivos de Neuro-Psiquiatria

Paulo Thadeu Brainer-lima¹  Alessandra Mertens Brainer-lima¹  Hildo Rocha Azevedo-filho¹ 

[1] ,University of Pernambuco Hospital da Restauração Division of Neurosurgery

关键词: ganglioglioma;    refractory epilepsy;    low-grade brain tumors;    ganglioglioma;    epilepsia refratária;    tumor cerebral de baixo grau;   

DOI  :  10.1590/S0004-282X2006000400018

来源: SciELO

【 摘 要 】

METHOD: Forty-two patients with low-grade brain tumor and refractory epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19) and group B, patients with other low-grade tumors (n=23) (14 astrocytoma, 6 oligodendroglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastrocytoma). RESULTS: Age at seizure’s onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045). Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively). Seizure’s frequency was higher in group B (p=0.002).Computerized tomography (CT) was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI) was abnormal in all patients. Surgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in group B. CONCLUSION: The association of refractory epilepsy and complex partial seizures, at a relatively low frequency, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.

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