Juvenile dermatomyositis: clinical, laboratorial, histological, therapeutical and evolutive parameters of 35 patients

Arquivos de Neuro-Psiquiatria

Adriana Maluf Elias Sallum¹  Maria Helena Bittencurt Kiss¹  Silvana Sachetti¹  Maria Bernadate Dutra Resende¹  Kelly Cristina Moutinho²  Mary De Souza Carvalho¹  Clovis Arthur Almeida Silva¹  Suely Kazue Nagahashi Marie¹ 

[1] ,University of São Paulo Medical School Laboratory of Neurological InvestigationSão Paulo SP ,Brazil

关键词: juvenile dermatomyositis;    clinical findings;    muscle biopsy;    treatment;    evolution;    outcome;    dermatomiosite juvenil;    achados clínicos;    biópsia muscular;    tratamento;    evolução;    prognóstico;   

DOI  :  10.1590/S0004-282X2002000600001

来源: SciELO

【 摘 要 】

This study was based on a prospective and a retrospective analysis of 35 patients who met Bohan and Peter criteria for juvenile dermatomyositis diagnosis.The mean follow-up time was three years ten months. Calcinosis was present in five (14.28 %) patients, cutaneous ulcers in four (11.42%), and systemic involvement in nine (27.71%) patients. All patients presented alterations in the serum levels of muscle enzymes, and all of them were submitted to muscle biopsy as a diagnostic procedure. Nine (25.71%) patients received corticotherapy prior to and 26 (74.28%) after the muscle biopsy. Chloroquine, methotrexate, cyclosporine, cyclophosphamide and intravenous immunoglobulin were used in patients with poor response to corticotherapy. Continuation of cutaneous manifestations was observed in 4 (11.43%) patients, laboratorial activity in 1 (2.85%), cutaneous and laboratorial activities in 3 (8.57%). Ten (28.57%) patients were out of activity, and 17 (48.57%) in remission at study end-point, on March 2002. Two (5.71%) patients died.

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