IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis

Arquivos de Neuro-Psiquiatria

Luís R. Machado²  José A. Livramento²  Adelaide J. Vaz¹  Ednéia C. Bueno¹  Sylvia R. Mielli²  Vitória Bastouly²  José Paulo S. Nóbrega² 

[1] ,University of São Paulo Faculty of Medicine Department of NeurologySão Paulo SP ,Brazil

关键词: neurocysticercosis;    cysticercosis;    cerebrospinal fluid;    IgG;    ELISA;    passive hemagglutination;    intrathecal synthesis;    oligoclonal bands;    specific antibody index;    neurocisticercose;    cisticercose;    líquido cefalorraqueano;    IgG;    ELISA;    hemaglutinação passiva;    síntese intratecal;    bandas oligoclonais;    índice de anticorpos específicos;   

DOI  :  10.1590/S0004-282X2002000300011

来源: SciELO

【 摘 要 】

We analyzed cerebrospinal fluid (CSF) and blood serum from 55 patients with neurocysticercosis (NC) at different clinical stages. According to inflammatory activity in the CSF, three stages were identified: (1) reactive, when there was at least an increase in the number of cells; (2) weakly reactive, when significant alterations were found in the CSF, including an increase in gamma globulins, albeit without hypercytosis; (3) non-reactive, when there was neither hypercytosis nor increase in gamma globulins. Nineteen patients had the reactive form; 18 had the weakly reactive form; 18 displayed the non-reactive form. Local immunoproduction was intense in the reactive group, moderate in the weakly reactive group, and absent in the non-reactive group. The specific antibody index was raised in approximately 2/3 of patients with the reactive form, 2/3 in those with the weakly reactive form, and 1/3 in those with the non-reactive form. In conclusion: (1) the classical CSF syndrome in NC can present both in complete and partial modes; (2) local immunoproduction can occur in weakly reactive forms; (3) a raised specific antibody index can occur in the absence of an inflammatory reaction in the CSF.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License