Arquivos de Neuro-Psiquiatria | |
IgG intrathecal synthesis and specific antibody index in patients with neurocysticercosis | |
Luís R. Machado2  José A. Livramento2  Adelaide J. Vaz1  Ednéia C. Bueno1  Sylvia R. Mielli2  Vitória Bastouly2  José Paulo S. Nóbrega2  | |
[1] ,University of São Paulo Faculty of Medicine Department of NeurologySão Paulo SP ,Brazil | |
关键词: neurocysticercosis; cysticercosis; cerebrospinal fluid; IgG; ELISA; passive hemagglutination; intrathecal synthesis; oligoclonal bands; specific antibody index; neurocisticercose; cisticercose; líquido cefalorraqueano; IgG; ELISA; hemaglutinação passiva; síntese intratecal; bandas oligoclonais; índice de anticorpos específicos; | |
DOI : 10.1590/S0004-282X2002000300011 | |
来源: SciELO | |
【 摘 要 】
We analyzed cerebrospinal fluid (CSF) and blood serum from 55 patients with neurocysticercosis (NC) at different clinical stages. According to inflammatory activity in the CSF, three stages were identified: (1) reactive, when there was at least an increase in the number of cells; (2) weakly reactive, when significant alterations were found in the CSF, including an increase in gamma globulins, albeit without hypercytosis; (3) non-reactive, when there was neither hypercytosis nor increase in gamma globulins. Nineteen patients had the reactive form; 18 had the weakly reactive form; 18 displayed the non-reactive form. Local immunoproduction was intense in the reactive group, moderate in the weakly reactive group, and absent in the non-reactive group. The specific antibody index was raised in approximately 2/3 of patients with the reactive form, 2/3 in those with the weakly reactive form, and 1/3 in those with the non-reactive form. In conclusion: (1) the classical CSF syndrome in NC can present both in complete and partial modes; (2) local immunoproduction can occur in weakly reactive forms; (3) a raised specific antibody index can occur in the absence of an inflammatory reaction in the CSF.
【 授权许可】
CC BY
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