Helicobacter pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy: an open randomized clinical trial

Arquivos de Gastroenterologia

Laura Cidrão Frota²  Maria Do Perpétuo Socorro Saldanha Da Cunha¹  Carlos René Lima Luz²  Antonio Haroldo De Araujo-filho²  Luciano A. S. Frota²  Lucia Libanez Bessa Campelo Braga² 

[1] ,Department of Internal Medicina

关键词: Helicobacter pylori;    Helicobacter infections;    Tetracycline;    Furazolidone;    Amoxicillin;    Azithromycin;    Proton pumps;    Helicobacter pylori;    Infecções por Helicobacter;    Tetraciclina;    Furazolidona;    Amoxicilina;    Azitromicina;    Bombas de próton;   

DOI  :  10.1590/S0004-28032005000200009

来源: SciELO

【 摘 要 】

BACKGROUND: Optimal anti-Helicobacter pylori treatment has not yet been established. AIM: To evaluate H. pylori eradication using tetracycline and furazolidone versus amoxicillin and azithromycin in lansoprazole based triple therapy in northeastern of Brazil. PATIENTS AND METHODS: One hundred and four patients with H. pylori infection, as determined by rapid urease testing and histology, were randomly assigned to receive either: lansoprazole (30 mg q.d.), tetracycline (500 mg q.i.d.), and furazolidone (200 mg t.i.d.) for 7 days (LTF; n = 52); or lansoprazole (30 mg b.i.d.) and amoxicillin (1 g b.i.d.) for 1 week, plus azithromycin (500 mg q.d.) for the first 3 days (LAAz; n = 52). H. pylori eradication was assessed 3 months following completion of therapy by means of rapid urease testing, histology and a 14C-urea breath test. RESULTS: H. pylori eradication was achieved in 46 of 52 (88.4%, 95% CI: 77.5%-95.1%) patients in LTF group and in 14 of 52 (26.9%, 95% CI: 16.2%-40,1%) patients in LAAz group. On a per-protocol analysis, eradication rates were 91.8% (95% CI: 81.4%-97.3%) and 28.5% (95% CI: 17.2%-42.3%), respectively in LTF and LAAz groups. CONCLUSION: The LAAz regimen yielded unacceptably low eradication rates. On the other hand, the LTF scheme represents a suitable alternative for H. pylori eradication.

【 授权许可】

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