Enhancement of sodium intestinal secretion in relation to absorption in malnourished rats: hyperosmolar challenge

Arquivos de Gastroenterologia

Rebeca C De Angelis²  José Vicente Martins Campos¹  Regina N. Rogano²  Geza G. Giuli²  Ilza C. M. Terra²  Julieta H. Scialfa¹  Itamar Klemps-filho¹ 

[1] ,Universidade de São Paulo

关键词: Intestinal secretions;    Nutrition disorders;    Sodium;    Intestinal absorption;    Rats;    Secreções intestinais;    Distúrbios nutricionais;    Sódio;    Absorção intestinal;    Ratos;   

DOI  :  10.1590/S0004-28031999000400010

来源: SciELO

【 摘 要 】

Two experimental models were tried in young malnourished rats in order to study effect of an hyperosmolar challenge in the small intestine on the bi-directional fluxes of sodium. Weanling rats were fed with energy restricted diets. In model I 1 mL of NaCl 900 mOsm/kg was introduced in the small intestine of the rats and left from 5 up to 70 min, in order to determine the moment of higher net Na+ secretion, which occurred at 10 min. In model II, the bi-directional fluxes of Na+ and Cl- were studied using NaCl or mannitol 900 mOsm/kg under the effect of mecholil, atropine or 2-4 dinitrophenol, for 10 min. Mecholil decreased the Na+ absorption enhancing the net secretion. Control rats were used as reference. In the restricted diets animals occurred an increase of the net secretion stimulated by NaCl 900 mOsm/kg, and this effect was enhanced by mecholil. It is suggested that in malnutrition there is an impairment in Na- intestinal absorption.

【 授权许可】

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