Absorption and metabolism of genistin in the isolated rat small intestine

FEBS Letters

Andlauer, Wilfried¹  Fürst, Peter¹  Kolb, Jochen¹ 

[1] Institute for Biological Chemistry and Nutrition, University of Hohenheim, Garbenstrasse 30, D-70593 Stuttgart, Germany

关键词: Intestinal absorption;    Genistin;    Isoflavone;    Intestinal metabolism;    Rat;   

DOI  :  10.1016/S0014-5793(00)01642-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 μmol/l. The intestinal absorption of genistin was 14.9% (±2.3, n=9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein. Sulfate derivatives of genistein or genistin were not observed.

【 授权许可】

Unknown