Impression cytology in the evaluation of ocular surface tumors: review article

Arquivos Brasileiros de Oftalmologia

Jeison De Nadai Barros¹  Simone Ribeiro Araújo De Almeida¹  Marcia Serva Lowen¹  Marcelo Carvalho Da Cunha¹  José Álvaro Pereira Gomes¹ 

关键词: Conjunctiva;    Cornea;    Limbus corneae;    Conjunctival neoplasms/diagnosis;    Eye neoplasms;    Cytodiagnosis;    Cytological techniques;    Diagnostic techniques;    ophthalmological;    Review;    Túnica conjuntiva;    Córnea;    Limbo da córnea;    Neoplasias da túnica conjuntiva/diagnóstico;    Neoplasias oculares;    Citodiagnóstico;    Técnicas citológicas;    Técnicas de diagnóstico oftalmológico;    Revisão;   

DOI  :  10.5935/0004-2749.20150033

来源: SciELO

【 摘 要 】

Impression cytology (IC) has been widely used as a method for evaluating the ocular surface and superficial cells layers in the diagnosis and follow-up after treatment of several ocular surface tumors of both epithelial and melanocytic origin. Information regarding this can be found in the English-language literature since 1992. Using either cellulose acetate or Biopore membranes for specimen collection, a high correlation has been found between IC and tissue histology. Compared with exfoliative cytology with spatula, IC is less traumatic to the patient’s eye, provides a precise location of the area being studied, and allows accurate observation of the cells the way they exist in vivo. The additional advantage of IC is the preservation of limbal stem cells responsible for continuous corneal epithelium renewal; these can be affected after incisional or excisional biopsy at the corneoscleral limbus, which is the most frequent site of appearance of tumors in the stratified epithelium. Treatment for ocular surface squamous neoplasia has historically included surgery, but nonsurgical interventions have also been adopted. Hence, in certain cases, ophthalmologists may prefer interventions less invasive than surgical biopsy such as of impression cytology for both initial diagnosis and therapeutic monitoring of treatment for ocular surface lesions. Nevertheless, it should be considered that IC may be less helpful if the results conflict with the clinical picture or if the clinical diagnosis is uncertain and results are negative. In such cases, surgical biopsy is required for accurate diagnosis. The purpose of this review is to examine the published literature on the utilization of IC for the diagnosis and management of ocular surface tumors and to discuss the requirement for further investigation on the subject.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License