New approaches and potential treatments for dry age-related macular degeneration

Arquivos Brasileiros de Oftalmologia

Francisco Max Damico²  Fabio Gasparin¹  Mariana Ramos Scolari¹  Lycia Sampaio Pedral¹  Beatriz Sayuri Takahashi¹ 

[1] ,University of São Paulo Medical School São Paulo SP ,Brazil

关键词: Macular degeneration;    Retina;    Retinal pigment epithelium;    Inflammation;    Complement activation;    Degeneração macular;    Retina;    Epitélio pigmentado da retina;    Inflamação;    Ativação do complemento;   

DOI  :  10.1590/S0004-27492012000100016

来源: SciELO

【 摘 要 】

Emerging treatments for dry age-related macular degeneration (AMD) and geographi c atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuroprotection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. Neuroprotective drugs, such as ciliary neurotrophic factor, brimonidine tartrate, tandospirone, and anti-amyloid β antibodies, aim to prevent apoptosis of retinal cells. Oxidative stress and depletion of essential micronutrients are targeted by the Age-Related Eye Disease Study (AREDS) formulation. Visual cycle modulators reduce the activity of the photoreceptors and retinal accumulation of toxic fluorophores and lipofuscin. Eyes with dry age-related macular degeneration present chronic inflammation and potential treatments include corticosteroid and complement inhibition. We review the current concepts and rationale of dry age-related macular degeneration treatment that will most likely include a combination of drugs targeting different pathways involved in the development and progression of age-related macular degeneration.

【 授权许可】

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