New insights into Vogt-Koyanagi-Harada disease

Arquivos Brasileiros de Oftalmologia

Francisco Max Damico²  Felipe Theodoro Bezerra²  Gaspar Carvalho Da Silva¹  Fábio Gasparin¹  Joyce Hisae Yamamoto¹ 

[1] ,University of São Paulo Medical School Hospital das Clínicas

关键词: Uveomeningoencephalitic syndrome;    Uveitis;    Chronic disease;    Autoimune diseases;    HLA-DR antigens;    Melanocytes;    Review;    Síndrome uveomeningoencefálica;    Uveíte;    Doença crônica;    Doenças autoimunes;    Antígenos HLA-DR;    Melanócitos;    Revisão;   

DOI  :  10.1590/S0004-27492009000300028

来源: SciELO

【 摘 要 】

Vogt-Koyanagi-Harada disease (VKH), a well-established multiorgan disorder affecting pigmented structures, is an autoimmune disorder of melanocyte proteins in genetically susceptible individuals. Several clinical and experimental data point to the importance of the effector role of CD4+ T cells and Th1 cytokines, the relevance of searching a target protein in the melanocyte, and the relevance of the HLA-DRB1*0405 in the pathogenesis of the disease. Vogt-Koyanagi-Harada disease has a benign course when early diagnosed and adequatey treated. Full-blown recurrences are rare after the acute stage of Vogt-Koyanagi-Harada disease is over. On the other hand, clinical findings, such as progressive tissue depigmentation (including sunset glow fundus) and uveitis recurrence, indicate that ocular inflammation may persist after the acute phase. Additionally, indocyanine green angiography findings suggest the presence of choroidal inflammation in eyes without clinically detectable inflammation. The aim of this paper is to review the latest research results on Vogt-Koyanagi-Harada disease pathogenesis and chronic/convalescent stages, which may help to better understand this potentially blinding disease and to improve its treatment.

【 授权许可】

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