Rationale for anti-inflammatory therapy in dry eye syndrome

Arquivos Brasileiros de Oftalmologia

Cs De Paiva¹  Sc Pflugfelder² 

[1] ,Baylor College of Medicine Cullen Eye Institute Department of OphthalmologyHouston,Texas

关键词: Dry eye syndromes;    Inflammation;    Concentration osmolar;    Cyclosporine;    Doxycycline;    Cytokines;    Metalloproteases;    Anti-Inflammatory agents;    Síndromes do olho seco;    Inflamação;    Concentração osmolar;    Ciclosporina;    Doxiciclina;    Citocinas;    Metaloproteases;    Antiinflamatórios;   

DOI  :  10.1590/S0004-27492008000700017

来源: SciELO

【 摘 要 】

Dry eye is a multifactorial condition that results in a dysfunctional lacrimal functional unit. Evidence suggests that inflammation is involved in the pathogenesis of the disease. Changes in tear composition including increased cytokines, chemokines, metalloproteinases and the number of T cells in the conjunctiva are found in dry eye patients and in animal models. This inflammation is responsible in part for the irritation symptoms, ocular surface epithelial disease, and altered corneal epithelial barrier function in dry eye. There are several anti-inflammatory therapies for dry eye that target one or more of the inflammatory mediators/pathways that have been identified and are discussed in detail.

【 授权许可】

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