Ocular copper deposition associated with monoclonal gammopathy of undetermined significance: case report

Arquivos Brasileiros de Oftalmologia

Patrick F. Tzelikis²  Peter R. Laibson¹  Marco P. Ribeiro¹  Christopher J. Rapuano¹  Kristin M. Hammersmith¹  Elisabeth J. Cohen¹ 

[1] ,Universidade Federal de Minas Gerais Faculdade de Medicina Belo Horizonte MG

关键词: Copper;    Blood protein electrophoresis;    Descemet's membrane;    Gama-globulins;    Paraproteinemias;    Cobre;    Eletroforese de proteínas sangüíneas;    Membrana de Descemet;    Gamaglobulina;    Paraproteinemias;   

DOI  :  10.1590/S0004-27492005000400021

来源: SciELO

【 摘 要 】

To report a case of ocular copper deposition in both eyes at the level of Descemet's membrane associated with a monoclonal gammopathy of undetermined significance (MGUS). A 49-year-old white woman had golden-brown metallic dust-like deposits on Descemet's membrane of both eyes. A systemic examination revealed an elevated serum copper, normal serum ceruloplasmin and a normal level of total protein. Serum protein electrophoresis demonstrated a single peak (M-spike) in the gamma region (M-protein in serum = 11 g/l). Flow cytometric analysis of the marrow aspirate identified a monoclonal plasma cell population that represents approximately 2% of the total marrow cells consistent with the diagnosis of monoclonal gammopathy of undetermined significance. Copper deposits at the level of Descemet's membrane may be a finding in a patient with monoclonal gammopathy of undetermined significance.

【 授权许可】

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