Effects of primaquine and chloroquine on oxidative stress parameters in rats

Anais da Academia Brasileira de Ciências

Francianne Giovanella¹  Gabriela K. Ferreira¹  Samira D.t. De PrÁ¹  Milena Carvalho-silva¹  Lara M. Gomes¹  Giselli Scaini¹  Renata C. GonÇalves¹  Monique Michels¹  LetÍcia S. Galant¹  Luiza M. Longaretti¹  Ana Luiza Dajori¹  Vanessa M. Andrade¹  Felipe Dal-pizzol¹  Emilio L. Streck¹  Renan P. De Souza¹ 

关键词: primaquine;    chloroquine;    oxidative damage;    DNA damage;    antimalarial drugs;    primaquina;    cloroquina;    dano oxidativo;    dano ao DNA;    antimaláricos;   

DOI  :  10.1590/0001-3765201520140637

来源: SciELO

【 摘 要 】

Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.

【 授权许可】

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