In vitro antimalarial activity of six Aspidosperma species from the state of Minas Gerais (Brazil)

Anais da Academia Brasileira de Ciências

Maria Fâni Dolabela²  Salma G. Oliveira¹  José M. Peres¹  José M.s. Nascimento¹  Marinete M. Póvoa¹  Alaide B. Oliveira¹ 

[1] ,Universidade Federal do Pará ICS Faculdade de FarmáciaBelém PA ,Brasil

关键词: antimalarial activity;    Plasmodium falciparum;    In vitro assays;    Aspidosperma spp.;    Apocynaceae;    atividade antimalárica;    Plasmodium falciparum;    ensaios in vitro;    Aspidosperma spp.;    Apocynaceae;   

DOI  :  10.1590/S0001-37652012000400005

来源: SciELO

【 摘 要 】

Ethnomedicinal informations point to some Aspidosperma species (Apocynaceae) as antimalarial plants in Brazil and have motivated the evaluation of six species which were collected in the state of Minas Gerais: A. cylindrocarpon Müll. Arg., A. parvifolium A. DC., A. olivaceum Müll. Arg., A. ramiflorum Müll. Arg., A. spruceanum Benth. ex Müll. Arg. and A. tomentosum Mart.. A total of 23 extracts of different plant parts in different solvents were assayed in vitro against chloroquine-resistant (W2) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum. All the extracts were shown to be active with IC50 values in the range of 5.0 ± 0 2.8 µg/mL to 65.0 ± 4.2 µg/mL. TLC profile of the extracts revealed the presence of alkaloids in the six species assayed. These results seem to confirm the popular use of Aspidosperma species to treat human malaria in Brazil and seem point to alkaloids as the putative active compounds of the assayed species.

【 授权许可】

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