Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Anais da Academia Brasileira de Ciências

Paulo Michel P. Ferreira¹  Leticia V. Costa-lotufo²  Manoel O. Moraes²  Francisco W.a. Barros²  Aline M.a. Martins²  Alberto J. Cavalheiro²  Vanderlan S. Bolzani²  Andre G. Santos²  Claudia Pessoa² 

[1] ,Universidade Federal do Piauí Campus Senador Helvídio Nunes de Barros Departamento de Ciências BiológicasPicos PI ,Brasil

关键词: Casearia sylvestris;    folk uses;    pharmacological properties;    Casearia sylvestris;    uso popular;    propriedades farmacológicas;   

DOI  :  10.1590/S0001-37652011005000040

来源: SciELO

【 摘 要 】

Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License