The pilocarpine model of epilepsy: what have we learned?

Anais da Academia Brasileira de Ciências

Fulvio A. Scorza¹  Ricardo M. Arida²  Maria Da Graça Naffah-mazzacoratti¹  Débora A. Scerni¹  Lineu Calderazzo¹  Esper A. Cavalheiro¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina São Paulo SP ,Brasil

关键词: hippocampus;    pilocarpine;    temporal lobe epilepsy;    rat;    hipocampo;    pilocarpina;    epilepsia do lobo temporal;    rato;   

DOI  :  10.1590/S0001-37652009000300003

来源: SciELO

【 摘 要 】

The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioral and electrographic changes that can be divided into 3 distinct periods: (a) an acute period that built up progressively into a limbic status epilepticus and that lasts 24 h, (b) a silent period with a progressive normalization of EEG and behavior which varies from 4 to 44 days, and (c) a chronic period with spontaneous recurrent seizures (SRSs). The main features of the SRSs observed during the long-term period resemble those of human complex partial seizures and recurs 2-3 times per week per animal. Therefore, the pilocarpine model of epilepsy is a valuable tool not only to study the pathogenesis of temporal lobe epilepsy in human condition, but also to evaluate potential antiepileptogenic drugs. This review concentrates on data from pilocarpine model of epilepsy.

【 授权许可】

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