Functional role of a glycolipid in directional movements of neurons

Anais da Academia Brasileira de Ciências

Rosalia Mendez-otero¹  Marcelo F. Santiago¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho Laboratório de Neurobiologia Celular e MolecularRio de Janeiro,Brasil

关键词: Glycolipid;    Ganglioside;    9-O-acetyl GD3;    Neuronal Migration;    Neurite outgrowth;    Development;    Glicolipídeo;    gangliosídeo;    9-O-acetyl GD3;    migração neuronal;    crescimento de neuritos;    desenvolvimento;   

DOI  :  10.1590/S0001-37652001000200007

来源: SciELO

【 摘 要 】

Migration of neurons from their site of origin to their final destination is a critical and universal step in the formation of the complex structure of the nervous system. The migratory process is thought to be governed in part by genetically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neuronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migration. Some molecules, such as cell adhesion molecules and motor proteins, may contribute to discrete steps in the migration act; others, like extracellular signaling molecules, may regulate the activation and/or termination of the migration program. In this article we review findings from our group that demonstrate the functional role(s) of a specific glycolipid in neuronal migration and neurite outgrowth in the developing and adult nervous system.

【 授权许可】

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