Interactions between cationic liposomes and drugs or biomolecules

Anais da Academia Brasileira de Ciências

Ana Maria Carmona-ribeiro¹ 

[1] ,Universidade de São Paulo Instituto de Química Departamento de BioquímicaSão Paulo SP ,Brazil

关键词: interactions;    dioctadecyldimethylammonium bromide;    phospholipids;    liposomes;    drugs;    surfaces;   

DOI  :  10.1590/S0001-37652000000100005

来源: SciELO

【 摘 要 】

Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide (DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in the cationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteria and fungi at concentrations that barely affect mammalian cells in culture. Silica particles or polystyrene microspheres can be functionalized by coverage with DODAB bilayers or phospholipid monolayers. Negatively charged antigenic proteins can be carried by the cationic liposomes which generate a remarkable immunoadjuvant action. Nucleotides or DNA can be physically adsorbed to the cationic liposomes to be transferred to mammalian cells for gene therapy. An overview of the interactions between DODAB vesicles and some biomolecules or drugs clearly points out their versatility for useful applications in a near future.

【 授权许可】

CC BY   
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