Greater resistance of the rabbit antropyloric region to experimental acute gastric ischemia

Jornal Brasileiro de Patologia e Medicina Laboratorial

Maria Angélica B. Magalhães²  Andy Petroianu¹  Juliano A. Figueiredo¹  Luiz R. Alberti¹  Alfredo J. A. Barbosa¹ 

[1] ,Universidade José do Rosário Vellano Medical School Belo Horizonte

关键词: experimental acute gastric ischemia;    gastric devascularization;    stomach;    gastric infarction;    rabbit;    isquemia gástrica experimental;    desvascularização gástrica;    estômago;    infarto gástrico;    coelho;   

DOI  :  10.1590/S1676-24442013000400009

来源: SciELO

【 摘 要 】

INTRODUCTION: Gastric ischemia represents an important medical challenge in pathology and surgical practice. OBJECTIVE: The purpose of this study was to assess the effects of acute gastric ischemia on different regions of the stomach. METHOD: Rabbit stomachs were subjected to devascularization of the greater and lesser curvatures for 3, 6 and 12 hours. After these periods, the stomachs were removed for macro and microscopic analysis. RESULTS: Hemorrhagic necrosis was more marked in the gastric fundus and body. In contrast, the antropylorus remained preserved in 100% of the rabbits after 3 hours of ischemia (group I), and in 80% of the rabbits after 6 and 12 hours of ischemia (groups II and III). Necrosis of the gastric body and fundus mucosa were observed in all animals after 6 and 12 hours of ischemia. CONCLUSION: We concluded that this experimental model of acute gastric ischemia was effective in producing hemorrhagic necrosis of the gastric fundus and body in rabbits even within a short period of time. Furthermore, the antropyloric region was preserved in most animals.

【 授权许可】

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